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Home Uncategorized High dose B vitamin, Biotin shows promise in Multiple Sclerosis

High dose B vitamin, Biotin shows promise in Multiple Sclerosis

Posted on August 4, 2015 Written by nhriordan 7 Comments

Mult Scler Relat Disord. 2015 Mar;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. Epub 2015 Jan 24.
High doses of biotin in chronic progressive multiple sclerosis: a pilot study.
Sedel F1, Papeix C2, Bellanger A3, Touitou V4, Lebrun-Frenay C5, Galanaud D6, Gout O7, Lyon-Caen O2, Tourbah A8.
Author information
Abstract
BACKGROUND:
No drug has been found to have any impact on progressive multiple sclerosis (MS). Biotin is a vitamin acting as a coenzyme for carboxylases involved in key steps of energy metabolism and fatty acids synthesis. Among others, biotin activates acetylCoA carboxylase, a potentially rate-limiting enzyme in myelin synthesis.

OBJECTIVES:
The aim of this pilot study is to assess the clinical efficacy and safety of high doses of biotin in patients suffering from progressive MS.

STUDY DESIGN:
Uncontrolled, non-blinded proof of concept study

METHODS:
23 consecutive patients with primary and secondary progressive MS originated from three different French MS reference centers were treated with high doses of biotin (100-300mg/day) from 2 to 36 months (mean=9.2 months). Judgement criteria varied according to clinical presentations and included quantitative and qualitative measures.

RESULTS:
In four patients with prominent visual impairment related to optic nerve injury, visual acuity improved significantly. Visual evoked potentials in two patients exhibited progressive reappearance of P100 waves, with normalization of latencies in one case. Proton magnetic resonance spectroscopy (H-MRS) in one case showed a progressive normalization of the Choline/Creatine ratio. One patient with left homonymous hemianopia kept on improving from 2 to 16 months following treatment׳s onset. Sixteen patients out of 18 (89%) with prominent spinal cord involvement were considered as improved as confirmed by blinded review of videotaped clinical examination in 9 cases. In all cases improvement was delayed from 2 to 8 months following treatment׳s onset.

CONCLUSIONS:
These preliminary data suggest that high doses of biotin might have an impact on disability and progression in progressive MS. Two double-blind placebo-controlled trials are on going.

Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

KEYWORDS:
Biotin; Multiple sclerosis; Optic neuritis; Progressive; Visual evoked potentials

Filed Under: Uncategorized

Comments

  1. Dra. Evelyn Vargas says

    September 2, 2015 at 5:17 pm

    MI PADRE FUE DIAGNOSTICADO CON ELA, ESCLEROSIS LATERAL AMIOTRÓFICA, DESDE HACE TRES MESES APROXIMADAMENTE QUE POSIBILIDAD HAY DE UNA MEJORÍA EN LA PERDIDA DE SUS FUNCIONES AL SER TRATADO CON CELL MADRES, YA QUE SE VA A SOMETER A UN TRATAMIENTO CON CELL MADRES DEL TEJIDO ADIPOSO, YA QUE EL MEDICAMENTO QUE LE HAN DEJADO LE DA MUCHOS EFECTOS ADVERSOS, POR LO QUE ME GUSTARÍA SABER LOS RESULTADOS QUE HA VISTO EN PACIENTES CON ESTA ENFERMEDAD AL SER TRATADOS CON ESTE TIPO DE TRATAMIENTOS. GRACIAS

    Reply
  2. Helen Huntley says

    September 13, 2015 at 6:14 pm

    Hello Dr. Riordan,

    I am writing to you in hopes that you may be able to help my cousin Megan. She is in a nursing home with progressive MS, she is bedridden. I’ve read about stem cell treatments and am hoping that the newest treatments would help her. Our plans are to start a gofundme account, asking for donations that would help us get Megan to Panama, and pay for the treatments. We no it’s a longshot but, hoping for a miracle.
    Thank you,
    Helen Huntley

    Reply
  3. Bobby Friend says

    December 15, 2015 at 5:35 pm

    I need your help, I have a spinal cord injury due to gunshot, please contact me

    Reply
  4. Stephen Bridgman says

    February 23, 2016 at 9:42 pm

    My wife suffers from R.A. and I am trying to get help for her before it’s to late. She has gone through just about everything they have come up with but I can see her declining in health. Can you help us? We live in Sparks, Nevada. Thank you for taking the time to read this even if you can’t help us. Steve Bridgman

    Reply
  5. Stephen Bridgman says

    February 23, 2016 at 11:18 pm

    My wife suffers from R.A. and I am trying to get help for her before it’s to late. She has gone through just about everything they have come up with but I can see her declining in health. Can you help us? We live in Sparks, Nevada. Thank you for taking the time to read this even if you can’t help us.
    PS; I am begging for your help. I’m not a begging kind of man and God knows I have my own medical problems with pain however I’m 65.My life is about over however my wife Blanca is only 54 and deserves better. You see she has been suffering her whole life. I would gladly give myself for spare parts to give her a better way of life. Thanks for your time.
    Steve Bridgman

    Reply
    • nhriordan says

      September 24, 2016 at 6:26 am

      Stephen, here is link to clinical trial for R.A. https://clinicaltrials.gov/ct2/show/NCT01985464?term=NCT01985464&rank=1

      Reply
  6. Jack Campbell says

    June 14, 2016 at 10:13 pm

    I have knees and hip problems, I do have arthritis all from the military. But I now have Inclusion Body Myositis (IBM) is there any thing that may help me cope. I was 71 when the Dr. told me and I just turned 80 in Feb.

    Reply

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Neil Riordan, PhD

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